Higher doses are also more likely to cause GI symptoms, such as bloating, gas, and diarrhea, because excess creatine may not be fully absorbed and can linger in the digestive tract, drawing in water and contributing to these uncomfortable side effects
Finally, a number of inherited mutations in genes involved in carnitine shuttling and fatty acid oxidation pathways do not systematically result in carnitine depletion (such that carnitine supplementation may not help mitigate the symptoms) but lead to abnormal profiles of acylcarnitine esters in blood (35, 40)
Also learn what clinical studies with alpha-lipoic acid have shown for diabetes, neuropathy, weight loss, Alzheimer's disease, and other conditions
Since the medication slows digestion, staying hydrated helps keep things moving through your digestive tract, reducing the risk of constipation
Table S12
10.3390/antiox11050965 Antioxidants