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Strengthening eGFR Across Broader Patient Groups In SUMMIT , both eGFRcreat and eGFRcys rose by week 52 on tirzepatide, even in participants with baseline CKD

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Changes in viscosity suggest breakdown of the solution matrix or bacterial contamination producing biofilm

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Unlike naturally occurring peptide hormones, which are rapidly broken down by enzymes within minutes, retatrutide contains several engineered modifications that substantially extend its biological half-life