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Its structure incorporates two Aib substitutions (positions 2 and 12) that enhance resistance to DPP-4 degradation, along with an amido-linked C-20 di-acid fatty chain at Lys20 that facilitates high-affinity albumin binding, resulting in a half-life of approximately five days 32,34
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Cardiovascular manifestations evolve from hypertension and tachycardia to myocardial depression, profound bradyarrhythmias, widened QRS complexes, and refractory ventricular fibrillation if plasma levels exceed roughly 10 g/mL
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This psychological preference is valid and can influence adherence
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