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Because it stimulates the bodys own growth hormone production, dosing needs to stay within physiologic limits to avoid excess IGF-1. If levels climb too high, she notes, you might get symptoms such as fluid retention, joint stiffness, carpal tunnellike numbness, or mild insulin resistance, though these effects are uncommon with conservative dosing and regular monitoring

We hope that the launch of Wegovy will ease some of the pressures on the supply of GLP-1 medications by offering an option that is expressly for weight loss and therefore reducing off-label prescription of GLP-1 drugs licensed for type 2 diabetes, he said

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"In reality, optimal outcomes require dietary modifications, resistance training and healthy sleep habits." She added that while evidence supporting weight reduction, improved glycaemic control and cardiovascular risk reduction is robust, "careful patient selection and counselling are essential before initiating treatment"

But while these drugs have helped millions of Americans move closer to their weight loss goals, they can be accompanied by some unpleasantand often unexpectedside effects