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15 HAD symptoms broadly include weight loss, poor appetite, slow recovery from fatigue, lethargy, irritability, lack of willpower to start new tasks, slowed mental processes, dull affect, and impaired cognitive function

However, to avoid disrupting PNKPs critical role in neuronal repair, drug development could follow the approach used in CGRP antibodies: designing large-molecule antibodies to restrict the therapeutic effect to the peripheral blood system through the natural barrier of the bloodbrain barrier, ensuring safety and specificity [46]

For example, some studies have utilized neutrophil membrane-coated coenzyme Q10 nanoparticles to alleviate RIRI [13]

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JJ Dugoua is a naturopathic doctor in Toronto and has a PhD in Pharmaceutical Sciences