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Achieving these stringent endpoints, as outlined in the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE-II) consensus ( Research into mucosal healing has highlighted pathways involving interleukin-20 (IL-20), claudin-2 (CLDN2), and notoginsenoside R1 (NGR1) ( Figure 1 illustrates the differences in immune cell distribution within the intestinal crypts under homeostatic conditions compared with the inflammatory microenvironments of CD and UC

These arent new compounds (the first GLP-1 was approved in 2005), but the newest versions are far more powerful

doi: 10.1530/EJE-19-0566

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When oxidative stress overwhelms endogenous glutathione stores, hydrogen peroxide accumulates, leading to lipid peroxidation, inner hair cell ribbon synapse breakdown, and microvascular strain within the stria vascularis

Zepbound (tirzepatide) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity