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Proton pump inhibitors remain the first-line pharmacotherapy for GERD, with over 15 million Americans filling PPI prescriptions annually per FDA safety communication data [2]

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This approach gained traction particularly among users who experienced significant gastrointestinal side effects at standard doses

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10.3389/fphar.2021.772418 104

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Revista de Chimie, 70 (9), 31083114

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