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In the STEP 1 trial, semaglutide at 2.4 mg weekly produced nearly 15 percent average weight loss over 68 weeks

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While these medicationsincluding semaglutide (Ozempic, Wegovy, Rybelsus) and liraglutide (Victoza, Saxenda)are FDA-approved only for metabolic conditions, emerging research explores whether their anti-inflammatory properties and effects on brain glucose metabolism might slow cognitive decline

The 12 agents examined, which included three with approved indications for chronic weight management in people with overweight or obesity and nine that have not yet been approved for that purpose, all provided significant reductions in body weight in randomized, placebo-controlled trials, lead author Areesha Moiz, BSc (Jewish General Hospital and McGill University, Montreal, Canada), and colleagues report