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Side effects are mostly gastrointestinal and transient, consistent with the drug class

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Endocrinology 158(12):41394151 Noria SF et al (2023) Weight regain after bariatric surgery: scope of the problem, causes, prevention, and treatment

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More recently, the SELECT trial showed that semaglutide 2.4 mg reduced major adverse cardiovascular events in adults with overweight or obesity without diabetes