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KLOW peptide is investigated for its potential effects on mitochondrial biogenesis, metabolic regulation, and cellular energy homeostasis through activation of AMPK (AMP-activated protein kinase) and modulation of PGC-1 expression

Clinical data, specifically from the SUSTAIN-6 trial, confirms this transient but significant risk during the initial months of therapy

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MnSOD is encoded by the SOD2 gene mapping to chromosome 6

doi:10.1111/dom.16437 Pavli P, Triantafyllidou O, Kapantais E, Vlahos NF, Valsamakis G

doi: 10.3389/fmed.2026.1743905 Received 11 November 2025 Revised 15 April 2026 Accepted 27 April 2026 Published 13 May 2026 Volume 13 - 2026 Edited by Rong Jin, Penn State Milton S