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The contribution of oxidation in PD pathogenesis has also been supported through clinical studies reporting alterations in serum glutathione peroxidase and superoxide dismutase activities, together with high malondialdehyde (MDA) levels in PD patients 23,24
Aydemir B, Onaran I, Kiziler AR et al (2007) Increased oxidative damage of sperm and seminal plasma in men with idiopathic infertility is higher in patients with glutathione S-transferase Mu-1 null genotype
Gan J, Qu Y, Li J, Zhao F, Mu D
Many people wonder if they should choose one over the other or if taking them simultaneously is redundant
However, the authors of this study also concluded that the high attrition rate due to poor patient compliance and mode of administration indicated the lack of feasibility of this intervention and suggested another view that ALA should be neglected as a future study of potential prevention of CIPN if innovative methods and trial designs can be identified and pursued
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