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The enzyme DPP-4 clips GLP-1 at the N-terminus, inactivating it

It found that once patients had stopped using their medications, they not only regained weight, but their risk markers for diabetes and heart disease returned to their original levels in less than two years

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However, since Saxenda (liraglutide) became the first GLP-1 approved for weight loss in 2014, additional options like Wegovy (semaglutide) and Zepbound (tirzepatide) have also been approved for weight management

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