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As a dual GIP/GLP-1 receptor agonist, tirzepatide works through two pathways rather than one, which clinical trials have shown produces greater average weight loss compared to semaglutide alone

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GLP-1 medications also carry an FDA black box warning for risk of thyroid C-cell tumors, and should not be used by patients with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2 (MEN2)

Exenatide once weekly over 2 years as a potential disease-modifying treatment for Parkinson's disease: protocol for a multicentre, randomised, double blind, parallel group, placebo controlled, phase 3 trial: the 'Exenatide-PD3' study