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Debido al principio de precaucin basado en los datos animales, la FDA requiere que estos medicamentos incluyan una advertencia de recuadro negro (boxed warning) sobre el riesgo terico de tumores de clulas C tiroideas, indicando que se desconoce si estos hallazgos en roedores son relevantes para los humanos

This upregulation leads to an increased expression of lipogenic genes, including sterol regulatory element-binding proteins (SREBP1c) and diacylglycerol acyltransferase-2 (DGAT2), which suggests that miR-370 provides a further point of regulation of this pathway 86

Stem Cells 31 , 14081421 (2013)

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An elimination-based strategy is often more useful than universal restriction