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Co-occurring symptom clusters emerged, with Cluster 1 encompassing a mix of somatic and psychological symptoms (such as allergies, anxiety, and hypertension), Cluster 2 encompassing neuromuscular and metabolic symptoms (such as dehydration, headache, and hypoglycemia), and Cluster 3 focusing on gastrointestinal distress

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Gradientdose 5-amino-1-methylquinolinium treatment further enables investigation of doseresponse relationships between NNMT inhibition, NAD+ levels, and metabolic efficiency, improving mechanistic understanding and supporting targetbased research for metabolic diseases

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