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When paired with a healthy diet and regular exercise, some studies have shown that participants can lose around 10%-15% of their weight, with other studies showing that in those who were overweight or obese, 5.9% total body weight loss at three months and 10.9% at six months was achieved

Journal of the American Pharmacists Association , 52(2), e53-e63

These can be differentiated from each other by estimating plasma amino acids, urine orotic acid, and genetic testing [Figure 3]

Long-haul flights, time-zone changes, dehydration and disrupted sleep all increase oxidative stress

Tirzepatide more commonly causes loose stools or diarrhea, with nausea being much less common

PMID 25985235