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2010 Oct;18(4):195-206

In Phase 2, monotherapy at 4.5 mg/week reached 10.8% at 26 weeks

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This makes it the first triple hormone receptor agonist with published clinical data in humans

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Structurally it is built on a modified GIP backbone with non-coded residues (aminoisobutyric acid, -methylleucine) and a fatty-acid conjugate on a central lysine, which together extend its plasma half-life and reduce proteolytic degradation in laboratory assay systems