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Regulatory Context Research Use Status KLOW is not FDA approved for any therapeutic indication

Acknowledgements This publication was made possible by grant number NCI CA53783 from the National Institutes of Health and grant number T32 ES012878 from the National Institutes of Environmental Health Sciences, NIH

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Key Findings from the Clinical Trial The study, led by Christian Hendershot at USC's Institute for Addiction Science, showed that weekly injections of semaglutide compared to placebo: Reduced alcohol cravings significantly Decreased drinking quantity overall Lowered the frequency of heavy drinking days What makes these results particularly exciting is that the magnitude of semaglutide's effects appeared potentially greater than what is typically seen with existing FDA-approved medications for alcohol use disorder, even though the drug was only administered at the lowest clinical doses