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Interestingly, the level of P-gp expression in endothelial cells appears to be be under the control of Caveolin-1, a key scaffolding/trafficking protein that is composed of plasmalemmal cholesterol and sphingolipid-rich raft subdomains that take part in endocytosis of caveolae, which, in turn, control transcellular permeability of this bloodbrain interface [37, 68]
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