All of these GLP-1 effects (Figure 2) are potentially beneficial for patients with T2D, and have been sought exploited clinically with the development of GLP-1R agonists
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Topical retinoids can potentially provide very low levels of collagen, more efficient modalities include lasers, RF microneedling (correct depth & settings) as well as HIFU & biostimulatory injectables
Additionally, semaglutide is not recommended for individuals with type 1 diabetes or diabetic ketoacidosis, as it is specifically designed for managing type 2 diabetes
Further research, including controlled studies with proper single-compound comparison groups, is needed to validate any combined effect