Metabolic syndrome, characterized by abdominal obesity, elevated triglycerides, low HDL-C, hypertension, and insulin resistance, confers increased cardiovascular risk
The largest psychiatric meta-analysis to date 80 randomized controlled trials, over 107,000 patients also found significant improvements in restrained eating and emotional eating with GLP-1 medications compared to placebo ( Pierret et al., JAMA Psychiatry, 2025 )
Although hard numbers on how many people are using compounded versions of brand-name medications are notoriously difficult to find, Menon told me that pharmaceutical companies believe the market for these copycat drugs is fairly significant in size. Some of the really big telehealth companies have partnered directly with pharmaceutical companies to get branded versions of the drugs, Menon said
It is not an MHRA-licensed medicine and is not intended to diagnose, treat, cure or prevent any disease
Focus on protein, hydration, and non-scale victories to stay motivated
The use of metformin has also been linked with a lower risk of developing other neurodegenerative eye conditions, such as AMD (Maleki et al., 2017