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While a general warning stating that reducing the dose of background insulin secretagogue or insulin may be necessary to prevent hypoglycemia is listed in each product insert, specific guidance on how to dose adjust background therapies is not detailed
Your choice depends on whether you have type 2 diabetes, prediabetes, or simply want to pursue weight management without a metabolic condition diagnosis
Effect of SGLT-2 inhibitors on cardiac autonomic function in type 2 diabetes mellitus: A meta-analysis of randomized controlled trials
Common reasons to switch: wanting more weight loss (higher dose), insurance changes, or adding the CV risk reduction benefit
B.et al (2013)
Soluble fiber, in particular, increases fermentation in the colon, promoting short-chain fatty acids (SCFAs) like butyrate, which enhance GLP-1 release
