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While not direct drug side effects, these changes occur in the context of treatment and may be perceived as medication-related

In the STEP-4 randomized trial (Rubino and colleagues, JAMA, 2021), the 803 adults who switched to placebo at week 20 regained about 6.9 percent of body weight over the next 48 weeks, while those who continued semaglutide kept losing

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A conjugation of AITC to glutathione in planta might be non-enzymatic or catalysed by GSTs, as indicated by the AITC-induced upregulation of several GST-encoding genes 17,40,41 and similar to what was recently shown for indol-3-ylmethyl-ITC 35

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The WHOQOL-BREF questionnaire evaluated quality of life in physical, psychological, social and environmental domains, with scores ranging from 0 to 100