The colour change is typically benign and temporary, particularly during initial therapy
A study involving the TAM-resistant cell lines named MCF-7/LCC2 and MCF-7/LCC9 reported that the combined use of curcumin and TAM resulted in synergistic growth inhibition, an increase in the sensitivity of MCF-7/LCC2 and MCF-7/LCC9 cells to TAM, and a reduction in IC 50 of TAM (Jiang et al., 2013)
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Uneven Skin Tone Support: May help improve the appearance of discoloration as part of an uneven skin tone treatment plan
If that happens, the accessibility of these drugs could expand rapidly across global populations
As of July 2026 there is no FDA-approved Lipo-C product and no approved weight-loss indication for the combination