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The increased gallstone risk appears to be associated with several factors: Altered bile composition due to rapid fat metabolism Increased cholesterol saturation in bile Changes in gallbladder function during weight loss Patients should be aware that these risks are not unique to weight loss injections any method of rapid weight loss, including very low-calorie diets or bariatric surgery, carries similar gallstone-related risks

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Supplementary material The Supplementary Material for this article can be found online at: Abbreviations AUD, Alcohol Use Disorder