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The documented example is the Tesamorelin + Ipamorelin protocol

HPA axis dysfunction can be caused by various factors , including: Chronic stress: Prolonged exposure to stress, as well as an accumulation of stress from different factors, can lead to an overstimulation of the HPA axis, eventually causing its dysregulation

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To the same extent, the non-intensification of treatment after suboptimal glycaemic control (therapeutic inertia) should also be evaluated considering its impact on the management and control of chronic conditions such as diabetes [16]

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