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Mild side effects noted in clinical trials have included bloating or mild cramps, gas and/ or loose stools, potential weight gain, and flushed skin

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The body's absorption mechanism involves intrinsic factora glycoprotein secreted by gastric parietal cellswhich facilitates absorption of approximately 1.52 micrograms per meal in the terminal ileum, with additional amounts absorbed through passive diffusion at about 1% of the remaining dose

Further, treating mice with dietary GR (0.1% GR food pellets) during juvenile and adolescent stages has been shown to prevent LPS-induced depression-like behaviors in adulthood (132, 136)

Both are biologically plausible, and both have limited supportive human evidence

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