Cocaine and amphetamines (stimulants) All animal studies retrieved for stimulants misuse involved exendin-4 among GLP-1RAs and highlighted a reduction of cocaine and amphetamines intake and end effects (for example, increased locomotor activity) via modulation of dopaminergic transmission in areas including the nucleus accumbens and the ventral tegmental area 91,92,93,94,96,97,98,99,100,101,102,103,105 , as well as modulation of inflammatory mechanisms 104
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143 The trials recruited adult participants with T2DM and significantly reduced body weight and improved blood sugar control in these patients
Glatstein M, Bonifacio Rino P, de Pinho S, Scolnik D, Pivko-Levi D, Hoyte C