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Semaglutide (found in Ozempic and Wegovy) is a GLP-1 (glucagon-like peptide-1) receptor agonist, mimicking a single natural gut hormone to reduce appetite, slow gastric emptying, and improve insulin secretion
The peptide also activates alternative angiogenic pathways including VEGF-independent routes via Src-caveolin-1-eNOS signaling, providing redundant mechanisms for vascular regeneration
Skin sensitivity causes anxiety
Most reported cases are anecdotal or involve patients with pre-existing gastric motility disorders
It remains in Phase 3 clinical trials under Eli Lilly's TRIUMPH program
However, persistent controversies surround its therapeutic efficacy and underlying molecular mechanisms
