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Glutathione undergoes a reaction with the toxic substances, facilitated by enzymes such as glutathione S-transferases, to form a conjugate known as a glutathione adduct, which is then further metabolized in the liver to form mercapturic acid, a water-soluble compound that can be easily excreted through the urine

Long-term NSAIDs Regular oral NSAID use raises the risk of stomach ulcers, kidney problems, and cardiovascular events

Dambrova M, Makrecka-Kuka M, Vilskersts R, Makarova E, Kuka J, Liepinsh E

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Abdullah KM, Sharma G, Singh AP, Siddiqui JA (2025) Nanomedicine in Cancer Therapeutics, Current Perspectives from Bench to Bedside