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In this double-blind trial, participants were randomly assigned to either receive semaglutide or the matching placebo

and clinical obesity is obesity with a chronic negative health effect present according to a schedule of diagnostic criteria

This blocks histamine receptors before the injection triggers histamine release, essentially intercepting the reaction before it can start

However, 2024 clinical practice guidelineswhich were endorsed by the American Society of Anesthesiologists and several other professional medical societiesexplain that this blanket recommendation is not necessary

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