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Unlike MSCs, which undergo senescence after a limited number of passages or with aging [59, 62], MSC-Exos do not exhibit signs of senescence and are more cost-effective and easier to produce at scale for clinical applications [63, 64]

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Neurology is particularly high stakes: the EVOKE and EVOKE+ Phase 3 trials of semaglutide in early Alzheimers disease, due in 202526, will be the first large-scale cognitive readouts