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Melatonin is mainly produced during the dark phase, and the maximal plasma concentration of this serotonin-derived hormone usually occurs 45 h after darkness onset 11

The excellent clinical manifestations of Tan IIA provide supportive evidence for targeting the GSH system in the treatment of heart diseases, which may be promising for transforming natural compounds from basic research to clinical applications

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Yuan et al., 2016)

Liver histology Liver tissue was fixed overnight in 10% formaldehyde, transferred to 70% ethanol for 48 h and then processed into paraffin blocks

Glutathione S-transferase isoenzymes in research-subject lung tumors