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doi: 10.1038/s42255-024-01113-9 19

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There may be ways to reduce a persons risk or reduce the severity of some side effects, including: Dizziness Flushing Headache or migraine Fatigue or extreme sleepiness Feeling restless If these side effects are severe or continue beyond the initial treatment period, a person may want to discuss them with their doctor

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The antiallodynic effect was long-lasting, with a peak effect at 1 h post-gavage and a duration exceeding 4 h [71]

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The latter enrolled 190 patients with obesity (mean age 54.4 years, mean BMI 36.1 kg/m 2 ) and biopsy-proven MASH and moderate-to-severe fibrosis regardless of the presence of T2D, showing a BW reduction of 10.7%, 13.3%, 15.6% and 0.8% at 52 weeks with tirzepatide 5 mg, 10 mg, 15 mg and placebo, respectively 39

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