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While the preclinical safety profile appears favorable (few adverse effects reported in animal studies), this does not guarantee the same in humans, especially with prolonged use
Glutathione/glutathione disulfide (GSH/GSSG) ratio and Nicotinamide adenine dinucleotide phosphate NADPH/NADP+ ratio were measured using GSH/GSSG Assay Kit (S0053, Beyotime) and NADP/NADPH Quantification Kit (S0179, Beyotime) respectively
J Clin Oncol 19 : 21892200 Baserga R (1994) Oncogenes and the strategy of growth factors