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Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood pressure in nondiabetic patients with mild to moderate hypertension
This effect seems to be dose-related, as patients receiving 5 mg daily showed a mean reduction of about 100 cells/mcL, and those receiving 2.5 mg daily did not have a decrease in lymphocyte count
But the pharmacokinetics of subcutaneous peptide delivery depend on several factors that vary by location, and understanding these factors gives you an edge that compounds over time
The break helps prevent receptor desensitization
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