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Therefore, noting the lack of spontaneous oxidation of free GSH between the two EDTA-treated samples stored at 80 o C, this result also suggests that the differences in GSH between the heparinized plasma (Preparation Condition 1) and deproteinized EDTA-treated plasma (Preparation Condition 2) are due to spontaneous oxidation of free GSH occurring in the heparinized plasma prior to the deproteinization process

From the clinical point of view symptoms were reduced in the 89 % of the patients

82,83 However, it has not been elucidated if insulin is locally synthesised in the brain or if it is transported from circulation in order to mediate any effects

Such alterations may lead to an enhanced potential of IGF-1 LR3, albeit possibly with a diminished duration of its active presence