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ATG14 was downregulated in 22Rv1 and Myc-CaP, and VTI1B in 22Rv1 only (Supplementary Figure S2B-C)

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Antioxidant enzymes such as superoxide dismutase 1 (SOD1), and glucose6phosphate dehydrogenase (G6PD) decrease from HMRD-induced oxidative stress (OxS) and protein degradation 50,51