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Biochem Biophys Res Commun 2017;490:247-52.ArticlePubMed 82

High-density lipoprotein cholesterol (HDL-C) changes are variable and generally minimal, with some studies showing slight increases and others showing no significant change

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NICE guidance recommends regular review of patients taking GLP-1 agonists, typically every 3-6 months, to assess treatment response, side effects, and ongoing appropriateness of therapy

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Superior weight loss: The combination consistently achieves ~2023% weight reduction, outperforming either drug alone and placing it among the strongest results in the obesity pharmacotherapy landscape (Reuters