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It also assists the liver in regenerating glutathione, which is essential for metabolizing toxins and maintaining steady detoxification pathways

10.1016/j.cell.2017.02.031 Cell 5 BorodkinaA

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These findings suggest that DMF, in addition to NRF2 activation on antioxidant response, could affect L2HGDH expression, L2HG and SAM levels to modify DNA 5mC and 5hmC modifications and CBS expression in SCD erythroblasts

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This amplification effect is why interactions involving enzyme inhibitors (such as certain antifungal drugs or even grapefruit juice) can lead to dramatic and dangerous increases in the plasma concentrations of co-administered high-extraction drugs