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J Biol Chem 279:4437044375 Carobbio S, Frigerio F, Rubi B et al (2009) Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis

Recommended dose: 1000-2000mg daily

Left ventricular hypertrophy and hypertension

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Melanotan-2: Broad Activation MT-2 activates all five melanocortin receptor subtypes : MC1R Melanin production (tanning) MC3R Energy homeostasis, sexual arousal MC4R Appetite regulation, sexual function, erectile response MC5R Sebaceous gland function This non-selective binding is why MT-2 produces tanning AND sexual effects AND appetite suppression AND nausea it's hitting every melanocortin pathway at once